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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided that they also experience weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes showed that patients had the average weight loss of four years old.1% rather than participants who were given placebos) during a 12- month period, while another study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you need to err to the side of caution and let the FDA do its job and demand some investigation be done in order that the public understands the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on his or her medications.

Researchers found out that participants investing in this drug for a year, dropped excess weight within four weeks and have kept the body weight off during the entire 56 weeks with the study. Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of more than one active ingredient, that might make them more potent and safer.

Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that as of right now there aren't long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and must not be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.